Our contributions to Chemical Biology range from the design and synthesis of unnatural nucleosides to probe the activity of immunological proteins, through to the design of fluorophores to probe mechanobiology systems. Currently our focus in this area is on the design and synthesis of probes for both lipidomics with Professor Riki Eggert in our department, and proteomics. An example of the latter is our work with GW Pharmaceutics where we are designing cannabinoid derivatives capable of covalent interaction with its target.
1) Parijat, P.; Kondacs, L.; Alexandrovich, A.; Gautel, M.; Cobb, A. J. A.; Kampourakis, T. High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle. ACS Chem. Biol. 2021, 16, 225.
2) Gadd, A. J. R.; Castelletto, V.; Kabova, E.; Shankland, K.; Perrie, Y.; Hamley, I.; Cobb, A. J. A.; Greco, F.; Edwards, A. D. High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation.
3) Gadd, A. J.; Greco, F.; Cobb, A. J. A.; Edwards, A. D. Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity.
4) Rangam, G.; Schmitz, K.-M.; Cobb, A. J. A.; Petersen-Mahrt, S. K. AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud.