The Cobb Research Lab

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    • Home
    • Andre
    • Research
    • Members
      • Current Members
      • Alumni
    • Photo Gallery
    • Publications
      • Publications 2020-present
      • Publications 2001-2019

The Cobb Research Lab

The Cobb Research LabThe Cobb Research LabThe Cobb Research Lab
  • Home
  • Andre
  • Research
  • Members
    • Current Members
    • Alumni
  • Photo Gallery
  • Publications
    • Publications 2020-present
    • Publications 2001-2019

Group Research

Chemical Biology

Our contributions to Chemical Biology range from the design and synthesis of unnatural nucleosides to probe the activity of immunological proteins, through to the design of fluorophores to probe mechanobiology systems. Currently our focus in this area is on the design and synthesis of probes for both lipidomics with Professor Riki Eggert in our department, and proteomics. An example of the latter is our work with GW Pharmaceutics where we are designing cannabinoid derivatives capable of covalent interaction with its target.

Read More Selected Examples

Kondacs, L.; Trentham, D. R.; Kampourakis, T; Cobb, A. J. A. Development of bifunctional fluorescent probes and their application to α-helix labelling. Org. Biomol. Chem. 2025, DOI: 10.1039/d5ob00563a


Varandas, P. A. M. M.; Belinha, R.; Cobb, A. J. A.; Ramalho, J. P. P.; Segundo, M. A.; Loura, L. M. S.; Silva, E. M. P. BBA Biomembranes 2024


Parijat, P.; Kondacs, L.; Alexandrovich, A.; Gautel, M.; Cobb, A. J. A.; Kampourakis, T. High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle. ACS Chem. Biol. 2021, 16, 225.


Gadd, A. J. R.; Castelletto, V.; Kabova, E.; Shankland, K.; Perrie, Y.; Hamley, I.; Cobb, A. J. A.; Greco, F.; Edwards, A. D. High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation.

Eur. J. Pharm. Sci., 2018, 123, 268.


Gadd, A. J.; Greco, F.; Cobb, A. J. A.; Edwards, A. D. Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity.

Bioconj. Chem., 2015, 26, 1743.


Rangam, G.; Schmitz, K.-M.; Cobb, A. J. A.; Petersen-Mahrt, S. K. AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud. 

PLoS ONE, 2012, e43279.


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