Research
Foldamer Design
Foldamers are synthetic peptides with the ability to form discrete secondary structures. Helical systems in particular have garnered much attention owing to their potential applications in a number of areas, from peptidomimetics to drug delivery, and catalysis through to information trasfer. Our interests lie in applying the unique monomers we have discovered through our synthetic methodology towards the construction of novel foldamers systems, and to apply them to one of the areas described above.
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Fanelli, R.; Berta, D.; Földes, T.; Rosta, E.; Atkinson, R. A.; Hofmann, H.-J.; Shankland, K.; Cobb, A. J. A. Organocatalytic Access to a cis-Cyclopentyl-γ-amino Acid: An Intriguing Model of Selectivity and Formation of a Stable 10/12-Helix from the Corresponding γ/α-Peptide.
J. Am. Chem. Soc., 2020, 132, 1382.
Lin, Q.; Lan, H.; Ma, C.; Stendall, R. T.; Shankland, K.; Musgrave, R. A.; Horton, P. N.; Baldauf, C.; Hofmann, H.-J.; Butts, C. P.; Mueller, M. M.; Cobb, A. J. A. Crystal Structure and NMR of an α,δ-Peptide Foldamer Helix Shows Side-Chains are Well Placed for Bifunctional Catalysis : Application as a Minimalist Aldolase Mimic. Angew. Chem. Int. Ed. 2023, e202305326.